cover image OVERDOSE: The Case Against the Drug Companies

OVERDOSE: The Case Against the Drug Companies

Jay S. Cohen, . . Putnam/Tarcher, $24.95 (318pp) ISBN 978-1-58542-123-7

Replete with information supported by recognized and reliable sources, this exposé-cum-health guide should be read by anyone taking prescription medication. Cohen, an associate professor of medicine and psychiatry at the University of California at San Diego, focuses on the practice of "standard dosing," i.e., the same number of milligrams prescribed for all patients; his articles about dosage have appeared in the New York Times and Newsweek. Asserting that different ages and conditions can affect how a drug is metabolized, and thus its effectiveness, Cohen advises to "Start Low, Go Slow." Lower doses often prove just as effective, and higher doses in the wrong person can be deadly. The chapters proceed logically, divided by families of drugs and, later, by FDA regulations, kickbacks to doctors from pharmaceutical companies, ghostwritten articles commissioned by pharmaceutical companies and attributed to independent doctors in trusted medical journals. Most importantly, Cohen discusses at length deadly and other irreversible side effects of new drugs, suggesting that warnings on drug packages are incomplete. He describes the pharmaceutical companies' practice of luring doctors to exotic weekend-long retreats for a two-hour symposium about a new product. Finally, Cohen gives insight into the doctor's Bible: The Physician's Desk Reference. Clear, easy narrative and anecdotal evidence makes this an accessible, albeit disturbing, read. This medical-biz gadfly delivers an invaluable resource for doctors and patients alike. (Oct. 15)

Forecast:Given its nearly limitless potential audience, and with a national author tour kicked off by an appearance on the radio talk show People's Pharmacy, prominent display in stores could make sales take off.